The rationale for testing drug combinations in aging intervention studies

Testing drug combinations to slow aging

Aging is a complex multifactorial process, meaning that multiple pathways need to be targeted to effectively prevent or slow aging [1]. A number of molecular pathways are well known for influencing aging, but only a few have been successfully targeted with individual drugs, and these drugs do not individually target all aging pathways. However, combinations of these drugs might have the potenti...

the search for the self in becketts theatre: waiting for godot and endgame

this thesis is based upon the works of samuel beckett. one of the greatest writers of contemporary literature. here, i have tried to focus on one of the main themes in becketts works: the search for the real "me" or the real self, which is not only a problem to be solved for beckett man but also for each of us. i have tried to show becketts techniques in approaching this unattainable goal, base...

AIDS : The economic rationale for public intervention

Many health professionals assume that the government should be involved in combatting the AIDS epidemic. While the case for government intervention may be clear to those in the health professions, many economists believe that too many resources have been invested in the fight against AIDS. It is useful to compare the case of AIDS with that of malaria. As The Economist recently noted, malaria ca...

Evaluation of several drug combinations for intraperitoneal anaesthesia in adult male rats

The objective of this study was to evaluate several drug combinations for intraperitoneal anaesthesia in laboratory rats. Following dose determination of anaesthetics in a pilot study, 45 healthy adult male rats were randomly assigned in 9 treatment groups and received propofol (alone or in combination with xylazine, midazolam, or ketamine) or ketamine (in combination with xylazine, midazolam, ...

The economic rationale for intervention in the tobacco market